The show frequently opens with opening act composing of a song either sung by Vice Ganda or another featured musician, and a dance performance onstage (commonly finalists from Vice's other show Showtime). Afterwards, the host introduces the show and the featured guests in the episode, including an unidentified guest who will star on the show later. After a commercial, guests are introduced during each of the show's segments. One segment, titled Vice Advice, features Vice and her guest/s giving advices to citizens onstage or from the show's official site in the social networking sites Facebook and Twitter. The segment ends with a composed song likewise giving a message to the latter. This segment changed its format on the show's fifth episode. In the new format, Vice will draw questions in a crystal ball containing questions that were posted by the followers on the show's Twitter and she will try to answer hilariously as many questions as she can for one minute. After that, she will present a certain issue and will ask an audience his/her opinion regarding the issue. The segment still ends with a composed song pertaining to the issue tackled.
After all guests have been interviewed, Vice closes the show with a challenge, wherein audience members participate in a game or prank to win various prizes. All segments are serenaded by a band led by musical director Marvin Querido.